Prenatal Screening for and Diagnosis of Down Syndrome (1996)

There is fair evidence to offer triple-marker screening through a comprehensive program to pregnant women under 35 years of age. Women given detailed information about the serum-marker screening show more satisfaction with the screening than those not given this information. (grade B recommendation)
There is fair evidence to odder amniocentesis or CVS to pregnant women 35 years of age and older and to women with a history of a fetus with DS or of a chromosome 21 anomaly. Information on the limitations and advantages of each procedure should be offered. Triple-marker screening may be offered as an alternative to CVS or amniocentesis to pregnant women over 35. (grade B recommendation)