Primary and Secondary Prevention of Neural Tube Defects (1994)

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  • All women of childbearing age should be advised to increase their consumption of folic acid through diet or supplementation to 0.4 mg/d beginning 1 month before pregnancy and ending at the start of the second trimester.
  • MSAFP screening is recommended in low-risk pregnancies only when it is part of a screening program that includes access to all necessary diagnostic services.
  • High-risk women should be referred to genetic counselling before they plan a pregnancy.